https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46022 300 inflammatory genes were similarly regulated in the uterine endometrium by mating independently of paternal diet, and 13 were dysregulated by HFD-fed compared with CD-fed males. Seminal vesicle fluid factors reduced in HFD-fed males, including TGF-β1, IL-10, and TNF, were among the predicted upstream regulators of differentially regulated genes. Additionally, the T-cell response induced by mating with CD-fed males was blunted after mating with HFD-fed males, with 27% fewer CD4⁺ T cells, 26% fewer FOXP3⁺CD4⁺ regulatory T cells (Treg) cells, and 19% fewer CTLA4⁺ Treg cells, particularly within the NRP1⁺ thymic Treg cell population. These findings demonstrate that an obesogenic HFD alters the composition of seminal vesicle fluid and impairs seminal plasma capacity to elicit a favorable pro-tolerogenic immune response in females at conception.]]> Wed 09 Nov 2022 11:05:03 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37681 Thu 27 Jan 2022 15:55:17 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37560 Thu 18 Feb 2021 11:00:21 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37559 Thu 18 Feb 2021 10:11:19 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37555 TGFBR2 encoding TGFB receptor 2. Conversely, TGFB1 suppressed IFNG receptor 1 and 2 genes IFNGR1 and IFNGR2. These data identify IFNG as a potent inhibitor of the TGFB-mediated seminal fluid interaction with relevant reproductive tract epithelia in mice and human. These findings raise the prospect that IFNG in the male partner's seminal fluid impairs immune adaptation for pregnancy following coitus in women.]]> Thu 18 Feb 2021 09:50:20 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37679 Fri 12 Mar 2021 10:57:58 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37676 Fri 12 Mar 2021 10:15:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37674 Fri 12 Mar 2021 10:01:58 AEDT ]]>